HORDB

ID: hor002222
Uniprot ID: P01308
Protein name: Insulin A chain
Gene name: INS
Organism: Homo sapiens (Human)
Family: Insulin family
Source: Human
Expression: NA
Disease: Diseases associated with INS include Hyperproinsulinemia and Maturity-Onset Diabetes Of The Young, Type 10.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0002020 protease binding; GO:0005158 insulin receptor binding; GO:0005159 insulin-like growth factor receptor binding; GO:0005179 hormone activity; GO:0005515 protein binding; GO:0042802 identical protein binding
GO BP: GO:0010629 negative regulation of gene expression
GO CC: NA

Sequence: GIVEQCCTSICSLYQLENYCN
Length: 21
Propeptide: MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Signal peptide: MALWMRLLPLLALLALWGPDPAAA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002222_AF2.pdb

hor002222_ESM.pdb

Mass:	274064	Formula:	C99H155N25O35S4
Absent amino acids:	ADFHKMPRW	Common amino acids:	C
pI:	3.61	Basic residues:	0
Polar residues:	12	Hydrophobic residues:	5
Hydrophobicity:	21.43	Boman Index:	-1785
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	88.1
Instability Index:	2254.29	Extinction Coefficient cystines:	3230
Absorbance 280nm:	161.5